Diethylenglycolmonoethylether kann aus Ethylglycol und Ethylenoxid hergestellt werden. Learn more. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone. A second opinion (SCCP/1200/08) on Diethylene glycol monoethyl ether (DEGEE) for its use as solvent in hair dye formulations was adopted on 16 December 2008 with the conclusion that: "The SCCP is of the opinion that the use of diethylene glycol monoethyl ether (DEGEE) as a Ethoxydiglycol can be classified as a glycol. 2020 Feb;13(2):22-29. USA.gov. Methods: Hey everyone, I am using ethoxydiglycol in a formula that contains dihydroxyacetone and its odor is very noticeable. 5.0 (1) "Customer service" "Great company" Contact Supplier. It is a solvent for dyes, nitrocellulose, paints, inks, and resins. * Used as a solvent and carrier in skin care products * Also known as Diethylene Glycol Monoethyl Ether Functions: According to RealSelf.com, Ethoxydiglycol is a clear, practically colorless, liquids used in cosmetics and personal care products.It is a solvent used to thin out products and decrease viscosity. Up to half of the applied solvent crosses the skin's barrier and becomes systemic. Diethylene glycol is metabolized in the liver by two consecutive oxidized form of nicotinamide adenine dinucleotide-dependent reactions.  |  Results: This substance is used in the following products: coating products, fillers, putties, plasters, modelling clay, perfumes and fragrances, cosmetics and personal care products, adhesives and sealants, washing & cleaning products, biocides (e.g. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Butylene Glycol ist ein Lösungsmittel, das feuchtigkeitsbindend wirkt. The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. It is miscible in water (at 25°C) and organic solvents. 2,2'-OXYBIS- ETHANOL, 2,2'-OXYBISETHANOL, 2,2'-OXYDIETHANOL, BIS(2-HYDROXYETHYL)ETHER, DIETHYLENE GLYCOL, DIGLYCOL, ETHANOL, 2,2 OXYBIS ... use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics: Japan's Standards for Cosmetics: Occupational hazards. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. diethylene glycol monoethyl ether was done by a member state (France). Epub 2018 Nov 12. and perfumes and cosmetics. Diethylene glycol monoethyl ether is asolubilising agent and an absorption enhancer used in veterinary medicine. Synonyms. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient. and you may need to create a new Wiley Online Library account. Dermatologists are already treating patients that apply products containing 5-40% of this solvent multiple times each day. An evaluation of dapsone gel 5% in the treatment of acne vulgaris. Skin Penetration and Permeation Properties of Transcutol®-Neat or Diluted Mixtures. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. For certain drug actives, this solvent provides for an intracutaneous depot. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Epub 2020 Feb 1. Background: Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. BACKGROUND: The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. To provide dermatologists a review of this solvent's safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Diethylene glycol monoethyl ether (Ethoxydiglycol) victoriayepez Member. Am J Clin Dermatol. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Ethyl Diglycol is used in the production & formulation of pesticides & wood preservaties. Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. Eigenschaften. Ethyl Ethyl BMK Powder Ethyl 2-phenylacetoacetate CAS 5413-05-8 Top Quality. The Role of Microstructure in Topical Drug Product Development. Print Share. Ethyl Carbitol is used in production of printing ink and as a cleaner in offset printing. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Background: AbstractBackgroundDiethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. It is also used in cosmetic & perfumary industry as a solvent. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use. Learn about our remote access options. It is an excipient used as a solubilising agent and an absorption enhancer. Commonly used in paints. Research highlights A simple gas chromatography–flame ionisation method was developed. » Diethylene Glycol Monoethyl Ether contains not less than 99.0 percent and not more than 101.0 percent of C 6 H 14 O 3.It is produced by condensation of ethylene oxide and alcohol, followed by distillation. Would you like email updates of new search results? It is an excipient to be used in an injectable product (containing a non-steroidal anti-inflammatory agent) for cattle and pigs at a concentration of 30%. 92.9%. Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate. 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